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Population variability in animal health: Influence on dose–exposure–response relationships: Part I: Drug metabolism and transporter systems
Author(s) -
Martinez Marilyn N.,
Court Michael H.,
FinkGremmels Johanna,
Mealey Katrina L.
Publication year - 2018
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12670
Subject(s) - population , drug , pharmacology , drug metabolism , disposition , session (web analytics) , medicine , biology , environmental health , psychology , computer science , social psychology , world wide web
Abstract There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose–exposure–response relationships and can affect the drug residues present in the edible tissues of food‐producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product recipients, both endogenous and exogenous variables need to be considered. The American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session during the 2017 Biennial meeting to explore the sources of population variability recognized to impact veterinary medicine. The following review highlights the information shared during that session. In Part I of this workshop report, we consider sources of population variability associated with drug metabolism and membrane transport. Part II of this report highlights the use of modeling and simulation to support an appreciation of the variability in dose–exposure–response relationships.