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Pharmacokinetic profiles of florfenicol in spotted halibut, Verasper variegatus , at two water temperatures
Author(s) -
Chang Zhiqiang,
Chen Zhao,
Gao Haiyu,
Zhai Qianqian,
Li Jian
Publication year - 2019
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12668
Subject(s) - florfenicol , pharmacokinetics , halibut , cmax , hippoglossus hippoglossus , bioavailability , oral administration , zoology , biology , pharmacology , chemistry , antibiotics , fishery , microbiology and biotechnology , fish <actinopterygii>
The pharmacokinetic profiles of florfenicol in the spotted halibut ( Verasper variegatus ) were investigated at 15 and 20°C water temperatures, respectively. Florfenicol content in plasma samples was analyzed using an HPLC method. Drug concentration versus time data were best fitted to a three‐compartment model after a single intravenous administration (15 mg/kg BW ), and fitted to a two‐compartment model after an oral administration (30 mg/kg BW ) at 15 and 20°C. The florfenicol concentration in the blood increased slowly during the 12 hr following an oral administration at 15°C, with a peak concentration ( C max ) of 9.1 mg/L, and then declined gradually. The half‐lives of absorption, distribution, and elimination phase were 2.18, 5.66 and 14.25 hr, respectively. The bioavailability ( F ) was calculated to be 24.14%. After an oral administration at 20°C, shorter half‐lives of absorption (1.33 hr), distribution (2.51 hr) and elimination (9.71 hr), a higher C max (12.2 mg/L), and a similar F (23.98%) were found. Based on the pharmacokinetics and pharmacodynamics, an oral dose of 30 mg/kg BW was suggested to be efficacious for bacterial disease control in spotted halibut farming.