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Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide ( DMSO ) in the horse following topical, oral, and intravenous administration
Author(s) -
Soma L. R.,
Robinson M. A.,
You Y.,
Boston R. C.,
Rudy J.
Publication year - 2018
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12476
Subject(s) - pharmacokinetics , absorption (acoustics) , dimethyl sulfoxide , chemistry , plasma concentration , oral administration , pharmacology , chromatography , medicine , physics , organic chemistry , acoustics
Compartmental models were used to investigate the pharmacokinetics of intravenous ( i.v. ), oral ( p.o. ), and topical ( TOP ) administration of dimethyl sulfoxide ( DMSO ). The plasma concentration–time curve following a 15‐min i.v. infusion of DMSO was described by a two‐compartment model. Median and range of alpha ( t 1/2α ) and beta ( t 1/2β ) half‐lives were 0.029 (0.026–0.093) and 14.1 (6.6–16.4) hr, respectively. Plasma concentration–time curves of DMSO following p.o. and TOP administration were best described by one‐compartment absorption and elimination models. Following the p.o. administration, median absorption ( t 1/2ab ) and elimination ( t 1/2e ) half‐lives were 0.15 (0.01–0.77) and 15.5 (8.5–25.2) hr, respectively. The plasma concentrations of DMSO were 47.4–129.9 μg/ml, occurring between 15 min and 4 hr. The fractional absorption ( F ) during a 24‐hr period was 47.4 (22.7–98.1)%. Following TOP administrations, the median t 1/2ab and t 1/2e were 1.2 (0.49–2.3) and 4.5 (2.1–11.0) hr, respectively. Plasma concentrations were 1.2–8.2 μg/ml occurring at 2–4 hr. Fractional absorption following TOP administration was 0.48 (0.315–4.4)% of the dose administered. Clearance (Cl) of DMSO following the i.v. administration was 3.2 (2.2–6.7) ml hr −1 kg −1 . The corrected clearances (Cl F ) for p.o. and TOP administrations were 2.9 (1.1–5.5) and 4.5 (0.52–18.2) ml hr −1 kg −1 .