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Suspected aspirin resistance in individual healthy adult warmblood horses
Author(s) -
Roscher K. A.,
Failing K.,
Schenk I.,
Moritz A.
Publication year - 2017
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12408
Subject(s) - warmblood , aspirin , medicine , horse , veterinary medicine , biology , paleontology
The reasons for this prospective experimental study were to determine a dosing scheme with loading and maintenance dose of aspirin inducing inhibition of platelet function measured by whole blood impedance aggregometry. Ten horses received aspirin orally in the morning with one loading dose of 4.7–5 mg/kg and maintenance doses of 1–1.3 mg/kg daily the following 4 days. Aggregometries ( COL test, ASPI test, ADP test) and serum salicylic acid were measured. ASPI test showed significant difference in inhibition at 24 and 48 hr ( p < .05) and 96 hr ( p < .01). Significant change for ADP test and COL test couldn't be detected. Serum salicylic acid concentrations were significantly ( p < .01) increased at 6 and 12 hr. Despite this, three horses failed any inhibitory effect of platelet function, suspecting an aspirin resistance. Regarding the other seven horses platelet aggregation induced by ASPI test was reduced between 37% and 100% from baseline at 6 and 12 hr and between 0 and 98% during the next 4 days. Correlations of serum concentration of salicylic acid and aggregometries couldn't be detected. It can be presumed that equine platelets are less susceptible to aspirin what may compromise eventually the anticoagulatory effects and efficacy in preventing and treating diseases with increased platelet activation as endotoxaemia or laminitis.