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The effects of dose and diet on the pharmacokinetics of omeprazole in the horse
Author(s) -
Sykes B. W.,
Underwood C.,
McGowan C. M.,
Mills P. C.
Publication year - 2017
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12345
Subject(s) - omeprazole , horse , pharmacokinetics , hay , crossover study , zoology , chemistry , plasma concentration , pharmacology , medicine , biology , paleontology , alternative medicine , pathology , placebo
This study aimed to investigate the effect of diet and dose on the pharmacokinetics of omeprazole in the horse. Six horses received two doses (1 and 4 mg/kg) of omeprazole orally once daily for 5 days. Each dose was evaluated during feeding either a high‐grain/low‐fibre ( HG / LF ) diet or an ad libitum hay ( HAY ) diet in a four‐way crossover design. Plasma samples were collected for pharmacokinetic analysis on days 1 and 5. Plasma omeprazole concentrations were determined by ultra‐high pressure liquid chromatography–mass spectrometry. In horses being fed the HG / LF diet, on day 1, the area under the curve ( AUC ) and maximal plasma concentration ( C max ) were higher on the 4 mg/kg dose than on the 1 mg/kg dose. The AUC was higher on day 5 compared to day 1 with the 4 mg/kg dose on the HG / LF diet. On days 1 and 5, the AUC and C max were higher in horses being fed the HG / LF diet and receiving the 4 mg/kg dose than in horses being fed the HAY diet and receiving the 1 mg/kg dose. These findings suggest that both dose and diet may affect pharmacokinetic variables of omeprazole in the horse.