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Pharmacokinetics of amoxicillin trihydrate in Thai swamp buffaloes (Bubalus bubalis) : a pilot study
Author(s) -
Ruennarong N.,
Wongpanit K.,
Sakulthaew C.,
Giorgi M.,
Klangkaew N.,
Poapolathep A.,
Poapolathep S.
Publication year - 2017
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12337
Subject(s) - bubalus , pharmacokinetics , dose , chemistry , zoology , body weight , veterinary medicine , pharmacology , chromatography , medicine , biology , ecology
This study aimed to investigate the pharmacokinetic characteristics of amoxicillin ( AMX ) in Thai swamp buffaloes, Bubalus bubalis , following single intramuscular administration at two dosages of 10 and 20 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 48 h. The plasma concentrations of AMX were measured by liquid chromatography–tandem mass spectrometry ( LC ‐ MS / MS ). The concentrations of AMX in the plasma were determined up to 24 h after i.m. administration at both dosages. The C max values of AMX were 3.39 ± 0.18 μg/ mL and 6.16 ± 0.18 μg/ mL at doses of 10 and 20 mg/kg, respectively. The AUC last values increased in a dose‐dependent fashion. The half‐life values were 5.56 ± 0.40 h and 4.37 ± 0.23 h at doses of 10 and 20 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK ‐ PD index (T > MIC ), i.m. administration of AMX at a dose of 20 mg/kg b.w might be appropriate for the treatment of susceptible Mannheimia haemolytica infection in Thai swamp buffaloes.