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The cardiopulmonary effects and quality of anesthesia after induction with alfaxalone in 2‐hydroxypropyl‐ β ‐cyclodextrin in dogs and cats: a systematic review
Author(s) -
Chiu K. W.,
Robson S.,
Devi J. L.,
Woodward A.,
Whittem T.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12312
Subject(s) - cats , propofol , medicine , anesthesia , anesthetic , heart rate , adverse effect , blood pressure
To systematically review the quality of evidence comparing the cardiopulmonary effects and quality of anesthesia after induction with alfaxalone vs. other anesthetic agents in dogs and cats. Studies published from 2001 until 20th May 2013 were identified with the terms ‘alfaxan’ OR ‘alfaxalone’ OR ‘alphaxalone’ in electronic databases: Discovery, PubMed, ScienceDirect, and Wiley Interscience. The study design and risk of bias of all included studies were assessed. Twenty‐two studies from 408 (22 of 408, 5.39%) satisfied the inclusion criteria. Fourteen studies (14 of 22, 64%) focused on dogs and nine (9 of 22, 40%) on cats. One study had both dogs and cats as subjects. (Hunt et al ., 2013) Twelve studies were rated an LOE 1, and six of these as ROB 1. One, seven, and two studies were rated as LOE 2, LOE 3, and LOE 5, respectively. In dogs, strong evidence shows that induction quality with either alfaxalone‐ HPCD or propofol is smooth. Moderate evidence supports this finding in cats. In dogs, moderate evidence shows that there is no significant change in heart rate after induction with either alfaxalone‐ HPCD or propofol. In cats, moderate evidence shows no significant difference in postinduction respiratory rate and heart rate between alfaxalone‐ HPCD and propofol induction. Strong evidence shows dogs and cats have smooth recoveries after induction using either alfaxalone‐ HPCD or propofol, before reaching sternal recumbency.