Premium
Evaluation of a fibrate, specific stimulant of PPAR α, as a therapeutic alternative to the treatment of clinical ovine pregnancy toxaemia
Author(s) -
Da Silva S.,
CalPereyra L. G.,
Benech A.,
AcostaDibarrat J.,
Martin M. J.,
Abreu M. C.,
Perini S.,
GonzálezMontaña J. R.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12304
Subject(s) - pregnancy , gestation , fetus , medicine , endocrinology , acute fatty liver of pregnancy , pharmacology , biology , genetics
Ovine pregnancy toxaemia is a metabolic disorder affecting sheep in their last 6 weeks of pregnancy as a result of their inability to maintain adequate energy homoeostasis. Different alternative treatments are available with variable results. The aim of this research was to evaluate a peroxisome proliferator‐activated receptor alpha ( PPAR α) stimulant as an alternative to treat clinical pregnancy toxaemia. Thirty‐three adult sheep, with known gestation date and carrying a single foetus, were fasted from day 130 of gestation until animals showed clinical disease. From that moment onwards, sheep were treated during 6 days with three different therapeutic alternatives: 10 mg/kg of 2‐methyl‐2‐phenoxy‐propionic acid; 10 mg/kg of 2‐methyl‐2‐phenoxy‐propionic acid + 100 mL of propylene glycol oral; or 100 mL of propylene glycol oral. Glycaemia and serum β‐hydroxybutyrate ( BHOB ) were determined daily. Liver biopsies were taken at day 130 of gestation, at the beginning and end of treatments and at 5 days postpartum, evaluating the extent and degree of the steatosis lesion. Even though in sheep treated with 2‐methyl‐2‐phenoxy‐propionic acid, serum concentrations of glucose and BHOB recovered more slowly, we conclude that 2‐methyl‐2‐phenoxy‐propionic acid alone or combined with propylene glycol can be used as an alternative to effectively treat fatty liver, and therefore pregnancy toxaemia.