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Pharmacokinetics, efficacy prediction indexes, and residue depletion of ribavirin in A tlantic salmon's ( S almo salar ) muscle after oral administration in feed
Author(s) -
San Martín B.,
Muñoz R.,
Cornejo J.,
Martínez M. A.,
ArayaJordán C.,
Maddaleno A.,
Anadón A.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12288
Subject(s) - pharmacokinetics , ribavirin , cmax , salmo , oral administration , plasma concentration , pharmacology , withdrawal time , zoology , ic50 , chemistry , medicine , biology , virus , virology , fishery , fish <actinopterygii> , biochemistry , hepatitis c virus , colorectal cancer , colonoscopy , cancer , in vitro
Ribavirin is an antiviral used in human medicine, but it has not been authorized for use in veterinary medicine although it is effective against infectious salmon anemia ( ISA ) virus, between others. In this study, we present a pharmacokinetic profile of ribavirin in Atlantic salmon ( Salmo salar ), efficacy prediction indexes, and the measure of its withdrawal time. To determine the pharmacokinetic profile, fishes were orally administered with a single ribavirin dose of 1.6 mg/kg bw, and then, plasma concentrations were measured at different times. From the time‐vs.‐concentration curve, Cmax = 413.57 ng/mL, T max = 6.96 h, AUC = 21394.01 μg·h/mL, t 1/2 = 81.61 h, and K 10 = 0.0421/h were obtained. Ribavirin reached adequate concentrations during the pharmacokinetic study, with prediction indexes of C max / IC 50 = 20.7, AUC / IC 50 = 1069.7, and T> IC 50 = 71 h, where IC is the inhibitory concentration 50%. For ribavirin depletion study, fishes were orally administered with a dairy dose of 1.6 mg/kg bw during 10 days. Concentrations were measured on edible tissue on different days post‐treatment. A linear regression of the time vs. concentration was conducted, obtaining a withdrawal time of 1966 °C days. Results obtained reveal that the dose of 1.6 mg/kg bw orally administered is effective for ISA virus, originating a reasonable withdrawal period within the productive schedules of Atlantic salmon.