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Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs
Author(s) -
Yata M.,
McLachlan A. J.,
Foster D. J. R.,
Page S. W.,
Beijerink N. J.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12243
Subject(s) - pharmacokinetics , metabolite , active metabolite , oral administration , dosing , pharmacology , heart failure , oral dose , plasma concentration , medicine , chemistry
Pimobendan is an inodilator used in the treatment of canine congestive heart failure ( CHF ). The aim of this study was to investigate the pharmacokinetics and cardiovascular effects of a nonaqueous oral solution of pimobendan using a single‐dose, operator‐blinded, parallel‐dose study design. Eight healthy dogs were divided into two treatment groups consisting of water (negative control) and pimobendan solution. Plasma samples and noninvasive measures of cardiovascular function were obtained over a 24‐h period following dosing. Pimobendan and its active metabolite were quantified using an ultra‐high‐performance liquid chromatography–mass spectrometer ( UHPLC ‐ MS ) assay. The oral pimobendan solution was rapidly absorbed [time taken to reach maximum concentration ( T max ) 1.1 h] and readily converted to the active metabolite (metabolite T max 1.3 h). The elimination half‐life was short for both pimobendan and its active metabolite (0.9 and 1.6 h, respectively). Maximal cardiovascular effects occurred at 2–4 h after a single oral dose, with measurable effects occurring primarily in echocardiographic indices of systolic function. Significant effects persisted for <8 h. The pimobendan nonaqueous oral solution was well tolerated by study dogs.