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Dispositions and tissue depletion of melamine in ducks
Author(s) -
Suknikom P.,
Jermnak U.,
Poapolathep S.,
Isariyodom S.,
Giorgi M.,
Kumagai S.,
Poapolathep A.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12242
Subject(s) - bioavailability , toxicokinetics , plasma concentration , chemistry , body weight , oral administration , kidney , high performance liquid chromatography , pharmacology , pharmacokinetics , medicine , chromatography
To evaluate the toxicokinetics and persistence of residues of melamine ( MEL ) in ducks, MEL was administered intravenously (i.v.) or orally (p.o.) to ducks at a dosage of 5.5 mg/kg body weight. The concentration of MEL in the plasma and various tissues was detected using HPLC equipped with an ultraviolet detector. The plasma concentration of MEL in ducks was determined up to 12 h after both i.v. and p.o. administrations. The average value of elimination half‐life ( t 1/2 β ) of MEL was 2.16 ± 0.37 and 2.01 ± 0.56 h after i.v. and p.o. administration, respectively. The absolute p.o. bioavailability was 90.79%. MEL was measurable in the liver and kidney after p.o. administration with maximum levels of 15.80 ± 1.81 and 15.49 ± 2.12 μg/g at 6 h, respectively. The results suggest that most of the administered MEL is efficiently absorbed from the gastro intestinal tract, and it has the ability to distribute into various tissues of the duck.