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Pharmacokinetics of cefuroxime after intravenous, intramuscular, and subcutaneous administration to dogs
Author(s) -
Albarellos G. A.,
Montoya L.,
Lorenzini P. M.,
Passini S. M.,
Lupi M. P.,
Landoni M. F.
Publication year - 2016
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12239
Subject(s) - pharmacokinetics , beagle , bioavailability , cefuroxime , intramuscular injection , medicine , plasma concentration , pharmacology , subcutaneous injection , chemistry , anesthesia , antibiotics , biochemistry
Cefuroxime pharmacokinetic profile was investigated in 6 Beagle dogs after single intravenous, intramuscular, and subcutaneous administration at a dosage of 20 mg/kg. Blood samples were withdrawn at predetermined times over a 12‐h period. Cefuroxime plasma concentrations were determined by HPLC . Data were analyzed by compartmental analysis. Peak plasma concentration ( C max ), time‐to‐peak plasma concentration ( T max ), and bioavailability for the intramuscular and subcutaneous administration were (mean ± SD ) 22.99 ± 7.87 μg/mL, 0.43 ± 0.20 h, and 79.70 ± 14.43% and 15.37 ± 3.07 μg/mL, 0.99 ± 0.10 h, and 77.22 ± 21.41%, respectively. Elimination half‐lives and mean residence time for the intravenous, intramuscular, and subcutaneous administration were 1.12 ± 0.19 h and 1.49 ± 0.21 h; 1.13 ± 0.13 and 1.79 ± 0.24 h; and 1.04 ± 0.23 h and 2.21 ± 0.23 h, respectively. Significant differences were found between routes for K a , MAT , C max , T max , t ½(a) , and MRT . T > MIC = 50%, considering a MIC of 1 μg/mL, was 11 h for intravenous and intramuscular administration and 12 h for the subcutaneous route. When a MIC of 4 μg/mL is considered, T > MIC = 50% for intramuscular and subcutaneous administration was estimated in 8 h.