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Effect of probiotics on enrofloxacin disposition in gastrointestinal tract of poultry
Author(s) -
Pavlova I.,
Danova S.,
Naidenski H.,
Tropcheva R.,
Milanova A.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12232
Subject(s) - enrofloxacin , probiotic , cmax , ciprofloxacin , pharmacokinetics , pharmacology , antibiotics , food science , medicine , biology , microbiology and biotechnology , bacteria , genetics
Probiotics are routinely used in poultry husbandry due to health benefit on the host. The gut microbiota is now recognized to exert an important influence on the absorption and pharmacokinetics of many compounds. Therefore, this study was designed to evaluate the effect of candidate probiotics belonging to the species L actobacillus brevis , L . plantarum and L . bulgaricus on pharmacokinetics of enrofloxacin in healthy chickens. The probiotic administration leads to higher degree of metabolism of enrofloxacin to ciprofloxacin in liver. The antibacterial drug was significantly faster absorbed (k ab of 0.61 ± 0.54 h −1 and T max 7.81 ± 3.52 h) at lower concentrations ( C max of 1.34 ± 0.18 μg·g −1 ) during the first 24 h of treatment in the probiotic's group. The values of k ab , T max , and C max for the group, treated solely with enrofloxacin, were 0.10 ± 0.065 h −1 , 15.42 ± 3.07 h, and 1.61 ± 0.24 μg·g −1 , respectively. A significantly higher concentration of enrofloxacin and its metabolite ciprofloxacin in the liver was observed in the group with the probiotic treatment. Disposition of both drugs was not significantly changed in the duodenum and in the jejunum. The selected dose is appropriate for treatment of infections caused by pathogens with MIC < 0.06 μg·mL −1 irrespective of antibiotic administration alone or in combination with probiotics.