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Pharmacokinetics of cefquinome in tilapia ( Oreochromis niloticus ) after a single intramuscular or intraperitoneal administration
Author(s) -
Shan Q.,
Zhu X.,
Liu S.,
Bai Y.,
Ma L.,
Yin Y.,
Zheng G.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12219
Subject(s) - tilapia , pharmacokinetics , oreochromis , volume of distribution , minimum inhibitory concentration , zoology , chemistry , plasma concentration , absorption (acoustics) , elimination rate constant , pharmacology , fish <actinopterygii> , medicine , biology , antibiotics , fishery , biochemistry , physics , acoustics
The pharmacokinetics of cefquinome was studied in plasma after a single dose (10 mg/kg) of intramuscular (i.m.) or intraperitoneal (i.p.) administration to tilapia ( Oreochromis niloticus ) in freshwater at 30 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two‐compartment open models following both routes of administration. The estimates of total body clearance (CL/F), volume of distribution (Vd/F), and absorption half‐life (T 1/2ka ) were 0.049 and 0.037 L/h/kg, 0.41 and 0.33 L/kg, and 0.028 and 0.035 h following i.m. and i.p. administration, respectively. After i.m. injection, the elimination half‐life (T 1⁄2β ) was calculated to be 5.81 h, the maximum plasma concentration (C max ) to be 49.40 μg/mL, the time to peak plasma cefquinome concentration (T max ) to be 0.14 h, and the area under the plasma concentration–time curve (AUC) to be 204.6 μg h/mL. Following i.p. administration, the corresponding estimates were 6.05 h, 44.39 μg/mL, 0.17 h and 267.8 μg h/mL. The minimum inhibitory concentrations of cefquinome, determined for 30 strains of Streptococcus agalactiae isolated from diseased tilapia, ranged from 0.015 to 0.12 μg/mL. Results from these studies support that 10 mg cefquinome/kg body weight daily could be expected to control tilapia bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of ≤2 μg/mL.