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Effects of food intake on pharmacokinetics of mosapride in beagle dogs
Author(s) -
Chae J.W.,
Song B.J.,
Baek I.H.,
Yun H.Y.,
Ma J. Y.,
Kwon K.I.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12200
Subject(s) - beagle , mosapride , pharmacokinetics , chemistry , oral administration , pharmacology , medicine
This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5‐mg oral dose of mosapride was administered to fasted ( n = 15) and fed ( n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography–tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis ( NCA ). Mosapride was absorbed in fasted and fed dogs with similar T max . Both C max and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/ mL vs. 2.76 μg/ mL ) and 3.5 times higher (38.53 h·μg/ mL vs. 10.22 h·μg/ mL ), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered.