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Dosage assessment of valnemulin in pigs based on population pharmacokinetic and Monte Carlo simulation
Author(s) -
Yuan L. G.,
Tang Y. Z.,
Zhang Y. X.,
Sun J.,
Luo X. Y.,
Zhu L. X.,
Zhang Z.,
Wang R.,
Liu Y. H.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12199
Subject(s) - pharmacokinetics , regimen , population , zoology , medicine , monte carlo method , population pharmacokinetics , pharmacology , chemistry , mathematics , statistics , biology , environmental health
To estimate the valnemulin pharmacokinetic profile in a swine population and to assess a dosage regimen for increasing the likelihood of optimization. This study was, respectively, performed in 22 sows culled by p.o. administration and in 80 growing‐finishing pigs by i.v. administration at a single dose of 10 mg/kg to develop a population pharmacokinetic model and Monte Carlo simulation. The relationships among the plasma concentration, dose, and time of valnemulin in pigs were illustrated as C i , v = X 0 (8.4191 × 10 ‐4 × e −0.2371 t + 1.2788 × 10 −5 × e −0.0069 t ) after i.v. and C p . o = X 0 (−8.4964 × 10 −4 × e −0.5840 t + 8.4195 × e −0.2371 t + 7.6869 × 10 −6 × e −0.0069 t ) after p.o. Monte Carlo simulation showed that T > MIC was more than 24 h when a single daily dosage at 13.5 mg/kg BW in pigs was administrated by p.o., and MIC was 0.031 mg/L. It was concluded that the current dosage regimen at 10–12 mg/kg BW led to valnemulin underexposure if the MIC was more than 0.031 mg/L and could increase the risk of treatment failure and/or drug resistance.