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Comparative pharmacokinetics of norfloxacin nicotinate in common carp ( Cyprinus carpio ) and crucian carp ( Carassius auratus ) after oral administration
Author(s) -
Xu N.,
Ai X.,
Liu Y.,
Yang Q.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12193
Subject(s) - crucian carp , cyprinus , pharmacokinetics , common carp , carp , carassius auratus , chemistry , zoology , biology , fishery , pharmacology , fish <actinopterygii>
Comparative pharmacokinetics of norfloxacin nicotinate ( NFXNT ) was investigated in common carp ( Cyprinus carpio ) and crucian carp ( Carassius auratus ) after a single oral dose of 10 mg/kg body weight (b.w.). Analyses of plasma samples were performed using ultra‐performance liquid chromatography ( UPLC ) with fluorescence detection. After oral dose, plasma concentration–time curves of common carp and crucian carp were best described by a two‐compartment open model with first‐order absorption. The pharmacokinetic parameters of common carp were similar to those of crucian carp. The distribution half‐life ( t 1/2 α ), elimination half‐life ( t 1/2 β ), peak concentration ( C max ), time‐to‐peak concentration ( T max ), and area under the concentration–time curve ( AUC ) of common carp were 1.58 h, 26.33 h, 6069.79 μg/L, 1.08 h, and 103072.36 h·μg/L, respectively, and those corresponding to crucian carp were 1.36 h, 26.55 h, 9586.06 μg/L, 0.84 h, and 126604.4 h·μg/L, respectively. These studies demonstrated that 10 mg NFXNT /kg body weight in common carp and crucian carp following oral dose presented good pharmacokinetic characteristics.