Premium
Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration
Author(s) -
PairisGarcia M. D.,
Johnson A. K.,
KuKanich B.,
Wulf L.,
Millman S. T.,
Stalder K. J.,
Karriker L. A.,
Coetzee J. F.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12170
Subject(s) - meloxicam , pharmacokinetics , cmax , bioavailability , oral administration , plasma concentration , pharmacology , high performance liquid chromatography , medicine , chemistry , half life , chromatography
The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (i.v.) and oral (p.o.) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3 ± 65.68 kg) were administered an i.v. or p.o. dose of meloxicam at a target dose of 0.5 mg/kg in a cross‐over design. Plasma samples collected up to 48 h postadministration were analyzed by high‐pressure liquid chromatography and mass spectrometry ( HPLC ‐ MS ) followed by noncompartmental pharmacokinetic analysis. Mean peak plasma concentration ( C MAX ) after p.o. administration was 1070 ng/mL (645–1749 ng/mL). T MAX was recorded at 2.40 h (0.50–12.00 h) after p.o. administration. Half‐life (T½ λ z ) for i.v. and p.o. administration was 6.15 h (4.39–7.79 h) and 6.83 h (5.18–9.63 h), respectively. The bioavailability (F) for p.o. administration was 87% (39–351%). The results of this study suggest that meloxicam is well absorbed after oral administration.