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Orally administered phenylbutazone causes oxidative stress in the equine gastric mucosa
Author(s) -
Martínez Aranzales J. R.,
Cândido de Andrade B. S.,
Silveira Alves G. E.
Publication year - 2015
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12168
Subject(s) - phenylbutazone , myeloperoxidase , malondialdehyde , oxidative stress , superoxide dismutase , glutathione , gastric mucosa , glutathione peroxidase , chemistry , antioxidant , pharmacology , stomach , nitric oxide , catalase , ulcer index , medicine , biochemistry , inflammation , enzyme
Phenylbutazone ( PBZ ) is widely used in equine medicine, and its side effects on the gastrointestinal tract are well known. The inhibition of prostaglandins and the oxidative stress induced by nonsteroidal anti‐inflammatory drugs ( NSAID s) are described as mechanisms of gastric mucosal injury in humans. In horses, only the secondary effect of changes in cyclooxygenases is related to gastric mucosal injury. The objective of this study was to evaluate the effect of PBZ on certain antioxidative/oxidative parameters of the gastric mucosa. The concentrations of antioxidants and oxidants (superoxide dismutase, SOD ; catalase, CAT ; nitric oxide, NO ; total glutathione, GSH ; myeloperoxidase, MPO ; and malondialdehyde, MDA ), PGE 2 levels, and the ulcerative lesions score were assessed. The results demonstrated decreased levels of antioxidant variables, increased levels of oxidant variables, and alterations in the prostaglandin E 2 ( PGE 2 ), myeloperoxidase ( MPO ), and glutathione ( GSH ) levels. In conclusion, PBZ induces oxidative stress in the gastric glandular mucosa of horses by changing the antioxidant–oxidant balance of this surface, which might be regarded as another mechanism of injury in the horse stomach.