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Intravenous infusion of electrolyte solution changes pharmacokinetics of drugs: pharmacokinetics of ampicillin
Author(s) -
Britzi M.,
Mazon Y.,
Lavy E.,
Soback S.
Publication year - 2014
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12122
Subject(s) - pharmacokinetics , ampicillin , elimination rate constant , beagle , chemistry , volume of distribution , bolus (digestion) , intravenous bolus , half life , chromatography , pharmacology , anesthesia , medicine , antibiotics , biochemistry
The pharmacokinetics of ampicillin in dogs was determined after intravenous (i.v.) bolus and constant rate infusion. Ampicillin was administered to six beagle dogs as an i.v. bolus at 20 mg/kg and as a constant rate i.v. infusion ( CRI ) at 20 mg/kg during 8 h (0.042 mL/min/kg) in R inger's lactate ( H artmann's) solution. The concentrations were determined by an LC / MS / MS method. After i.v. bolus, ampicillin total body clearance, apparent volume of distribution at steady‐state, mean residence time (MRT), and half‐life were 4.53 ± 0.70 mL/min/kg, 0.275 ± 0.044 L/kg, 61 ± 13 min, and 111 (85–169) min, respectively. The corresponding parameters calculated after CRI were 13.5 ± 1.06 mL/min/kg, 0.993 ± 0.415 L/kg, 73 ± 27 min, and 49 (31–69) min. Ampicillin concentration decreased by 30% in the R inger's lactate infusion solution mostly during the first hour after preparation of the solution. Constant rate infusion of R inger's lactate solution during 8 h caused significant changes in ampicillin pharmacokinetics. The results suggested that special attention should be given to drug pharmacokinetics when co‐administered intravenously with electrolyte solutions.