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Depletion study and estimation of the withdrawal period for enrofloxacin in pacu ( P iaractus mesopotamicus )
Author(s) -
Paschoal J. A. R.,
Quesada S. P.,
Gonçalves L. U.,
Cyrino J. E. P.,
Reyes F. G. R.
Publication year - 2013
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12043
Subject(s) - pacu , piaractus mesopotamicus , enrofloxacin , maximum residue limit , zoology , residue (chemistry) , withdrawal time , body weight , fish farming , ciprofloxacin , veterinary medicine , biology , chemistry , microbiology and biotechnology , fish <actinopterygii> , fishery , aquaculture , medicine , antibiotics , pesticide , pesticide residue , agronomy , biochemistry , genetics , colorectal cancer , colonoscopy , cancer , endocrinology
Defining the pharmacokinetic parameters and depletion intervals for antimicrobials used in fish will help in the development of important guidelines for future regulations by Brazilian agencies on the use of these substances in fish farming. This paper presents a depletion study for enrofloxacin ( ENR ) and its main metabolite, ciprofloxacin ( CIP ), in pacu ( P iaractus mesopotamicus ) fillets. The depletion study was carried out under monitored environmental conditions, with the temperature controlled at 27 °C to mimic the fish farming conditions in B razil. ENR was administered orally via medicated feed for 10 consecutive days at daily dosages of 10 mg/kg body weight (b.w.). The fish were slaughtered at 6, 12, and 24 h and 2, 3, 5, 8, 12, 17, and 24 days after the medication period. Considering a maximum residue limit of 100 μg/kg for the sum of the ENR and CIP residues in the fillet, the results obtained in the depletion study allowed the estimation of a half‐life for ENR of 2.75 days and a withdrawal period of 23 days. The results obtained in this study are important for the farming of pacu in tropical regions.