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Author(s) -
Punzi S.,
Mallem M.Y.,
Desfontis J.-C.,
BELLOLI C
Publication year - 2012
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/jvp.12004
Subject(s) - citation , library science , computer science , medicine
A substantial contribution of 5-hydroxytryptamine (5-HT) in the contractile response of bovine digital artery (BDA), as well as short- and longer-term changes in basal reactivity to the amine induced by endothelium removal, have been recently described. The present work investigated the vasomotor reactivity to 5-HT in bovine digital vein (BDV) in order to evaluate possible differential control by this amine in the two sides of vascular bed.\udThree main differences in BDA and BDV vascular reactivity to 5-HT were observed. (i) 5-HT induces more effective and potent contractile effects in BDV than in BDA; (ii) the endothelium removal induces short-term increased reactivity to 5-HT in BDA but not in BDV; (iii) significant but opposite long-term changes in contractile reactivity to 5-HT were recorded in incubated BDV (hyper-reactivity) and BDA (hypo-reactivity) that had been deprived of the endothelium before incubation.\udThe disclosed differential arterial/venous vasomotor control of 5-HT may contribute to the physiological haemodynamic regulation of the bovine foot as well as to the establishment of poor blood flow leading to laminitis