Open AccessSerum uromodulin in dogs with chronic kidney disease
Author(s) -
Seo Dansong,
Yang Yeseul,
Hwang SungHyun,
Jung JaeHa,
Cho Soyeon,
Choi Goeun,
Kim Yongbaek
Publication year - 2022
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16579
Subject(s) - tamm–horsfall protein , medicine , creatinine , kidney disease , area under the curve , renal function , confidence interval , gastroenterology , endocrinology , receiver operating characteristic , blood urea nitrogen , urology , kidney
Background Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs. Objective To evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs. Animals Forty‐nine dogs with CKD (International Renal Interest Society [IRIS] Stage 1, n = 23; Stage 2, n = 20; Stage 3‐4, n = 6) and 25 healthy controls. Methods Prospective, observational study. Serum uromodulin concentration was measured using a canine‐specific enzyme‐linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed. Results Serum uromodulin concentrations were significantly lower in the CKD group than in the control group ( P < .001), but no significant difference was observed among stages of CKD. A negative correlation was observed between serum uromodulin concentration and conventional renal markers (blood urea nitrogen concentration, r = −.60, P < .0001; serum creatinine concentration, r = −.46, P < .0001; serum symmetric dimethylarginine concentration [SDMA], r = −.65, P < .0001). In receiver operating characteristic analysis, the area under the curve (AUC) of uromodulin (AUC, 0.97; 95% confidence interval [CI], 0.94‐1.00) was higher than that of SDMA (AUC, 0.87; 95% CI, 0.79‐0.95) for CKD diagnosis ( P = .01). The AUC of uromodulin (AUC, 0.95; 95% CI, 0.89‐1.00) also was higher than that of SDMA (AUC, 0.72; 95% CI, 0.58‐0.87) in distinguishing dogs with Stage 1 CKD from controls ( P = .001). Conclusions and Clinical Importance Serum uromodulin concentration is decreased in dogs with CKD. Thus, serum uromodulin may be a valuable diagnostic marker for CKD in dogs, particularly in identifying early‐stage CKD.