Open AccessAssociations among serum insulin, calprotectin, and C‐reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra‐low‐fat diet
Author(s) -
Xenoulis Panagiotis G.,
Heilmann Romy M.,
Stavroulaki Eva M.,
Riggers Denise S.,
Gneipel Laura J.,
Suchodolski Jan S.,
Steiner Jörg M.
Publication year - 2022
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16418
Subject(s) - medicine , hyperlipidemia , c reactive protein , calprotectin , insulin , endocrinology , diabetes mellitus , inflammation , disease , inflammatory bowel disease
Background Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. Objectives Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are affected by dietary intervention in MS with HTGL. Animals Seventy MS with HTGL and 79 MS without HTGL. In addition, 15 MS with HTGL were placed on a low‐fat diet. Methods Serum concentrations of triglycerides, cholesterol, calprotectin, insulin, and glucose were compared between groups. Results Serum glucose and calprotectin concentrations (shown to be higher in MS with HTGL than in MS without HTGL) were inversely correlated ( ρ = −.28; P < .001). After dietary intervention, median serum insulin concentrations were 8.1 mU/L compared to 20.8 mU/L before dietary intervention ( P = .06). Dogs with complete resolution of HTGL after dietary intervention (5 dogs) had significantly lower serum insulin concentrations compared to baseline ( P = .03). Conclusion and Clinical Importance The subclinical inflammatory phenotype in MS with HTGL appears to be associated with IR. Resolution of HTGL by dietary intervention is associated with a decrease in serum insulin concentrations. The implication of the increase in serum calprotectin concentrations after resolution of HTGL warrants further study.