Open AccessClinical, laboratory and ultrasonographic findings differentiating low‐grade intestinal T‐cell lymphoma from lymphoplasmacytic enteritis in cats
Author(s) -
Freiche Valérie,
Fages Julien,
Paulin Mathieu Victor,
Bruneau Julie,
Couronné Lucile,
German Alexander J.,
Penninck Dominique,
Hermine Olivier
Publication year - 2021
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16272
Subject(s) - medicine , enteritis , lymphoplasmacytic lymphoma , cats , lymphoma , pathology , gastroenterology , waldenstrom macroglobulinemia
Abstract Background Low‐grade intestinal T‐cell lymphoma (LGITL) is the most common intestinal neoplasm in cats. Differentiating LGITL from lymphoplasmacytic enteritis (LPE) is challenging because clinical signs, laboratory results, diagnostic imaging findings, histology, immunohistochemistry, and clonality features may overlap. Objectives To evaluate possible discriminatory clinical, laboratory and ultrasonographic features to differentiate LGITL from LPE. Animals Twenty‐two cats diagnosed with LGITL and 22 cats with LPE based upon histology, immunohistochemistry, and lymphoid clonality. Methods Prospective, cohort study. Cats presented with clinical signs consistent with LGITL or LPE were enrolled prospectively. All data contributing to the diagnostic evaluation was recorded. Results A 3‐variable model ( P < .001) consisting of male sex ( P = .01), duration of clinical signs ( P = .01), and polyphagia ( P = .03) and a 2‐variable model ( P < .001) including a rounded jejunal lymph node ( P < .001) and ultrasonographic abdominal effusion ( P = .04) were both helpful to differentiate LGITL from LPE. Conclusions and Clinical Importance Most clinical signs and laboratory results are similar between cats diagnosed with LGITL and LPE. However, male sex, a longer duration of clinical signs and polyphagia might help clinicians distinguish LGITL from LPE. On ultrasonography, a rounded jejunal lymph node, and the presence of (albeit small volume) abdominal effusion tended to be more prevalent in cats with LGITL. However, a definitive diagnosis requires comprehensive histopathologic and phenotypic assessment.