Open AccessSelective symmetrical necrotizing encephalopathy secondary to primary mitochondrial disorder in a cat
Author(s) -
Dell'Era Elena,
Polidori Margherita,
Bernardini Marco,
Capomaccio Stefano,
Cappelli Katia,
Balducci Federica,
Mandara Maria T.
Publication year - 2021
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16222
Subject(s) - pathology , medicine , neuropathology , gliosis , spongiosis , astrogliosis , encephalopathy , brainstem , neuropil , mitochondrial dna , leukoaraiosis , pathogenesis , magnetic resonance imaging , biology , dementia , central nervous system , genetics , disease , gene , radiology
A 2‐year‐old female cat was referred for progressive neurological signs indicative of involvement of the prosencephalon, cerebellum, and brainstem. Magnetic resonance imaging identified multifocal, bilateral, symmetrical lesions with strong contrast enhancement, affecting multiple areas of the brain. Neuropathology at necropsy showed demyelination, necrotic lesions, spongiosis, and neuropil edema with reactive astrogliosis and neovascularization. Ultrastructural study indicated mitochondrial polymorphism. Genetic investigations outlined 2 polymorphisms within the tRNA‐Leu (UUR) gene of mitochondrial DNA. Imaging and neuropathological findings were consistent with selective symmetrical necrotizing encephalopathy, for which genetic investigations support mitochondrial pathogenesis.