Open AccessSerum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
Author(s) -
Zini Eric,
Salesov Elena,
Willing Anke,
Palizzotto Carlo,
Lutz Thomas A.,
Reusch Claudia E.
Publication year - 2021
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16119
Subject(s) - cats , medicine , acromegaly , insulin like growth factor , endocrinology , body weight , weight loss , radioimmunoassay , insulin , weight gain , growth factor , obesity , growth hormone , hormone , receptor
Abstract Background Measurement of serum concentrations of insulin‐like growth factor (IGF)‐1 is used to diagnose acromegaly in cats. Hypothesis Changes of body weight do not affect serum concentrations of IGF‐1 in cats. Animals Ten healthy purpose‐bred cats. Methods Prospective study. In lean cats, food availability was stepwise increased during the first week and given ad libitum for a total of 40 weeks to increase their body weight. From week 41 to week 60, food access was limited to reach a weight loss of 1% to 2% each week. Measurement of IGF‐1 was performed at week 0, 16, 40, and 60. Insulin‐like growth factor‐1 was measured by radioimmunoassay. Body weight and IGF‐1 were compared among the 4 time points. Results Body weight increased by 44% from week 0 (4.5 ± 0.4 kg) to week 40 (6.5 ± 1.2 kg) ( P < .001) and decreased by 25% from week 40 to week 60 (4.9 ± 0.7 kg) ( P < .001). Serum IGF‐1 concentrations did not differ during the study period (week 0, 16, 40, 60: 500 ± 188, 479 ± 247, 470 ± 184, 435 ± 154 ng/mL, respectively; P = .38). Correlations with body weight were not observed. Conclusions and Clinical Importance Insulin‐like growth factor‐1 might not be influenced by changes of body weight in healthy cats, possibly suggesting that the latter is unimportant when interpreting IGF‐1 results in this species.