Open AccessEvaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
Author(s) -
Boileau Melanie J,
Wagner Leslie,
Taylor Jared D
Publication year - 2021
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.16059
Subject(s) - azotemia , creatinine , medicine , repeatability , gold standard (test) , spectrum analyzer , venous blood , point of care , point of care testing , urology , renal function , zoology , chromatography , pathology , chemistry , biology , electrical engineering , engineering
Background There are no commercially available handheld blood creatinine analyzers validated in goats. Objectives The objective of the study was to validate the accuracy of a handheld point‐of‐care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia. Animals Sixty‐three goats admitted to a referral hospital. Methods Cross‐sectional study. Venous blood was obtained, and creatinine concentration was measured by the POC in duplicate. Plasma was submitted for creatinine determination via the chemistry analyzer (gold standard). Results A total of 101 blood samples were collected from 63 goats. There was high repeatability for creatinine concentrations obtained by the POC (adjusted R 2 = .97, P < .0001). Correlation of POC concentrations with those reported by the chemistry analyzer was moderate (adjusted R 2 = .57, P < .0001). When correctly categorizing goats with mild azotemia, the POC demonstrated a sensitivity of 73.3% and a specificity of 88.3%. For moderate to severe azotemia, the POC had a sensitivity of 75.0% and specificity of 97.5%. Conclusion and Clinical Importance The Nova StatSensor POC provided above average accuracy for measuring blood creatinine concentration in goats compared with the gold standard test.