Open AccessEffect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters
Author(s) -
Buhl Rikke,
Carstensen Helena,
Hesselkilde Eva Zander,
Klein Bjørg Zinkernagel,
Hougaard Karen Margrethe,
Ravn Kirsten Bomberg,
LoftAndersen Ameli Victoria,
Fenner Merle Friederike,
Pipper Christian,
Jespersen Thomas
Publication year - 2018
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.15137
Subject(s) - medicine , atrial fibrillation , cardiology , qrs complex , heart rate , tachycardia , fibrillation , blood pressure
Background Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. Objectives To quantify the effect of AF on maximum velocity ( V max ), maximum heart rate (HR max ), heart rate recovery ( T 100 ), hematologic parameters and development of abnormal QRS complexes. Animals Nine Standardbred trotters. Methods Two‐arm controlled trial. Six horses had AF induced by means of a pacemaker and 3 served as sham‐operated controls. All horses were subjected to an exercise test to fatigue before (SET1) and after (SET2) 2 months of AF or sham. The V max and HR max were assessed using a linear mixed normal model. Abnormal QRS complexes were counted manually on surface ECGs. Results Atrial fibrillation resulted in a 1.56 m/sec decrease in V max ( P < .0001). In the AF group, HR max ± SD increased from 226 ± 11 bpm at SET1 to 311 ± 27 bpm at SET 2. The AF group had higher HR max at SET2 compared with controls ( P < .0001), whereas no difference between the control and AF groups was observed at SET1 ( P = .96). Several episodes of wide complex tachycardia were observed during exercise in 3 of the AF horses during SET2. Conclusions and Clinical Importance Atrial fibrillation resulted in a significant reduction in performance, an increase in HR and development of abnormal QRS complexes during exercise, which may be a risk factor for collapse or sudden cardiac death.