Open AccessInvestigation of Known Genetic Mutations of Arabian Horses in Egyptian Arabian Foals with Juvenile Idiopathic Epilepsy
Author(s) -
Aleman M.,
Finno C.J.,
Weich K.,
Penedo M.C.T.
Publication year - 2017
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.14873
Subject(s) - foal , medicine , epilepsy , juvenile , juvenile myoclonic epilepsy , pediatrics , genetics , biology , psychiatry
Background The carrier status of lavender foal syndrome ( LFS ), cerebellar abiotrophy ( CA ), severe combined immunodeficiency ( SCID ), and occipitoatlantoaxial malformation ( OAAM 1) in foals with juvenile idiopathic epilepsy ( JIE ) is unknown. Hypothesis/Objectives To determine the carrier status of LFS , CA , SCID , and OAAM 1 in foals with JIE . Animals Ten foals with JIE . Materials and Methods Archived DNA samples were tested for known genetic mutations causing LFS , CA , SCID , and OAAM 1. The inclusion criteria consisted of having been diagnosed with JIE by ruling out other causes of seizures in foals and supported by electroencephalographic examination. Results Ten Egyptian Arabian horses (5 females and 5 males) were phenotyped as foals with JIE by electroencephalography ( EEG ). All foals were negative for the genetic mutations that cause LFS , CA , SCID , and OAAM 1 except for 1 foal that was a carrier of CA . Conclusions and Clinical Importance Juvenile idiopathic epilepsy of Egyptian Arabian foals and LFS appear to be phenotypically and genetically distinct disorders. There was no apparent association between JIE and LFS , CA , SCID , and OAAM 1.