Open AccessQuality Control of Compounded Crystalloid Fluids for Intravenous Delivery to Horses
Author(s) -
Magnusson C.B.,
Poulsen K.P.,
Budde J.A.,
Hartmann F.A.,
Aulik N.A.,
Raabis S.M.,
Moreira A.S.D.,
Darien B.J.,
Peek S.F.
Publication year - 2017
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.14864
Subject(s) - medicine , compounding , isotonic , contamination , isotonic solutions , intravenous fluid , sterile water , biological fluids , intensive care medicine , anesthesia , chromatography , pulp and paper industry , pharmacology , chemistry , ecology , engineering , biology
Background Periodic lack of availability and high cost of commercially produced isotonic fluids for intravenous ( IV ) use in horses have increasingly led to use of home‐made or commercially compound fluids by veterinarians. Data regarding the quality control and safety of compounded fluids would be of benefit to equine veterinarians. Objectives To compare electrolyte concentrations, sterility, and endotoxin contamination of commercially available fluids to 2 forms of compounded isotonic crystalloid fluids intended for IV use in horses. Methods Prospective study. Two methods of preparing compounded crystalloids formulated to replicate commercial Plasma‐Lyte A (Abbott, Chicago, IL) were compared. One formulation was prepared by a hand‐mixed method involving chlorinated drinking water commonly employed by equine practitioners, and the other was prepared by means of ingredients obtained from a commercial compounding pharmacy. The variables for comparison were electrolyte concentrations, sterility, and presence of endotoxin contamination. Results Electrolyte concentrations were consistent within each product but different between types of fluids ( P < 0.0001). Hand‐mixed fluids had significantly more bacterial contamination compared to commercial Plasma‐Lyte A ( P = 0.0014). One of the hand‐mixed fluid samples had detectable endotoxin contamination. Conclusions and Clinical Importance Chlorinated drinking water is not an acceptable source of water to compound isotonic fluids for IV administration. Equine practitioners should be aware of this risk and obtain the informed consent of their clients.