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Background  Dogs are a unique model for examining the effects of exercise on vitamin D status because of their lack of vitamin D synthesis by  UV  exposure. In addition, the inflammatory response may be associated with hypovitaminosis D.    Objectives  To investigate the effects of several days of endurance exercise on plasma vitamin D (25‐( OH )D 3 , 24,25‐( OH )D 3  and 1,25( OH )D 3 ) and serum C‐reactive protein ( CRP ) concentrations in stage‐stop racing sled dogs.    Animals  12 racing sled dogs and 8 control dogs.    Methods  Blood was collected before the race and immediately after racing on days 2 and 8. Plasma vitamin D metabolites and serum  CRP  concentrations were measured.    Results  Racing dogs showed a significant increase in 25( OH )D 3  on day 2 ( P  = .027) and day 8 of the race ( P  < .001), whereas no increases were observed in control dogs. The plasma concentration of 24,25( OH )D 3  showed a significant increase by day 8 ( P  < .001). There were no significant changes in 1,25( OH ) D 3  concentrations across all time points and groups. Racing dogs had significantly increased  CRP  concentrations by day 2 (39.3 ± 30.1 μg/mL;  P  < .001).    Conclusions and Clinical Importance  Increases in vitamin D metabolites as well as increases in  CRP  concentrations were observed in racing sled dogs. This finding was contrary to the hypothesis that decreases in vitamin D status in athletes may be related to the acute phase inflammatory response during exercise. In addition, the increased 24,25( OH )D 3  concentrations compared to what is observed in other species suggests metabolic variations in dogs that lead to enhanced disposal of vitamin D.

Plasma Vitamin D Metabolites and C‐Reactive Protein in Stage‐Stop Racing Endurance Sled Dogs