Open AccessGlomerular Filtration Rate, Urine Production, and Fractional Clearance of Electrolytes in Acute Kidney Injury in Dogs and Their Association with Survival
Author(s) -
Brown N.,
Segev G.,
Francey T.,
Kass P.,
Cowgill L.D.
Publication year - 2015
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.12518
Subject(s) - renal function , medicine , urology , excretion , acute kidney injury , urine , fractional excretion of sodium , kidney , urinary system , endocrinology
Background Acute kidney injury ( AKI ) is common in dogs. Few studies have assessed sequential changes in indices of kidney function in dogs with naturally occurring AKI . Objective To document sequential changes of conventional indices of renal function, to better define the course of AKI , and to identify a candidate marker for recovery. Animals Ten dogs with AKI . Methods Dogs were prospectively enrolled and divided into surviving and nonsurviving dogs. Urine production was measured with a closed system for 7 days. One and 24‐hour urinary clearances were performed daily to estimate solute excretion and glomerular filtration rate ( GFR ). Solute excretion was calculated as an excretion ratio ( ER ) and fractional clearance ( FC ) based on both the 1‐ and 24‐hour urine collections. Results Four dogs survived and 6 died. At presentation, GFR was not significantly different between the outcome groups, but significantly ( P = .03) increased over time in the surviving, but not in the nonsurviving dogs. Fractional clearance of Na decreased significantly over time (20.2–9.4%, P < .0001) in the surviving, but not in the nonsurviving dogs. The ER and FC of solutes were highly correlated ( r , 0.70–0.95). Conclusion and Clinical Impact Excretion ratio might be used in the clinical setting as a surrogate marker to follow trends in solute excretion. Increased GFR , urine production, and decreased FC of Na were markers of renal recovery. The FC of Na is a simple, noninvasive, and cost‐effective method that can be used to evaluate recovery of renal function.