English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  Acute kidney injury ( AKI ) is common in dogs. Few studies have assessed sequential changes in indices of kidney function in dogs with naturally occurring  AKI .    Objective  To document sequential changes of conventional indices of renal function, to better define the course of  AKI , and to identify a candidate marker for recovery.    Animals  Ten dogs with  AKI .    Methods  Dogs were prospectively enrolled and divided into surviving and nonsurviving dogs. Urine production was measured with a closed system for 7 days. One and 24‐hour urinary clearances were performed daily to estimate solute excretion and glomerular filtration rate ( GFR ). Solute excretion was calculated as an excretion ratio ( ER ) and fractional clearance ( FC ) based on both the 1‐ and 24‐hour urine collections.    Results  Four dogs survived and 6 died. At presentation,  GFR  was not significantly different between the outcome groups, but significantly ( P  = .03) increased over time in the surviving, but not in the nonsurviving dogs. Fractional clearance of Na decreased significantly over time (20.2–9.4%,  P  < .0001) in the surviving, but not in the nonsurviving dogs. The  ER  and  FC  of solutes were highly correlated ( r , 0.70–0.95).    Conclusion and Clinical Impact  Excretion ratio might be used in the clinical setting as a surrogate marker to follow trends in solute excretion. Increased  GFR , urine production, and decreased  FC  of Na were markers of renal recovery. The  FC  of Na is a simple, noninvasive, and cost‐effective method that can be used to evaluate recovery of renal function.

journal of veterinary internal medicine

Glomerular Filtration Rate, Urine Production, and Fractional Clearance of Electrolytes in Acute Kidney Injury in Dogs and Their Association with Survival