Open AccessComparison of Carboplatin and Doxorubicin‐Based Chemotherapy Protocols in 470 Dogs after Amputation for Treatment of Appendicular Osteosarcoma
Author(s) -
Selmic L.E.,
Burton J.H.,
Thamm D.H.,
Withrow S.J.,
Lana S.E.
Publication year - 2014
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.12313
Subject(s) - medicine , carboplatin , chemotherapy , doxorubicin , proportional hazards model , amputation , osteosarcoma , retrospective cohort study , cohort , surgery , oncology , cisplatin , pathology
Background Many chemotherapy protocols have been reported for treatment of canine appendicular osteosarcoma ( OSA ), but outcome comparisons in a single population are lacking. Objective To evaluate the effects of protocol and dose intensity ( DI ) on treatment outcomes for carboplatin and doxorubicin‐based chemotherapy protocols. Animals Four hundred and seventy dogs with appendicular OSA . Methods A retrospective cohort study was performed comprising consecutive dogs treated (1997–2012) with amputation followed by 1 of 5 chemotherapy protocols: carboplatin 300 mg/m 2 IV q21d for 4 or 6 cycles ( CARBO 6), doxorubicin 30 mg/m 2 IV q14d or q21d for 5 cycles, and alternating carboplatin 300 mg/m 2 IV and doxorubicin 30 mg/m 2 IV q21d for 3 cycles. Adverse events ( AE ) and DI were evaluated. Kaplan–Meier survival curves and Cox proportional hazards regression were used to compare disease‐free interval ( DFI ) and survival time ( ST ) among protocols. Results The overall median DFI and ST were 291 days and 284 days, respectively. A lower proportion of dogs prescribed CARBO 6 experienced AE s compared to other protocols (48.4% versus 60.8–75.8%; P = .001). DI was not associated with development of metastases or death. After adjustment for baseline characteristics and prognostic factors, none of the protocols provided a significant reduction in risk of development of metastases or death. Conclusions and Clinical Importance Although choice of protocol did not result in significant differences in DFI or ST , the CARBO 6 protocol resulted in a lower proportion of dogs experiencing AE s, which could be advantageous in maintaining high quality of life during treatment. DI was not a prognostic indicator in this study.