Open AccessEvaluation of Hemostatic Abnormalities in Canine Spirocercosis and Its Association with Systemic Inflammation
Author(s) -
Pazzi P.,
Goddard A.,
Kristensen A.T.,
Dvir E.
Publication year - 2013
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.12220
Subject(s) - medicine , neoplastic transformation , fibrinogen , neoplastic disease , pathology , c reactive protein , gastroenterology , acute phase protein , myocarditis , inflammation , cancer , carcinogenesis
Background Canine spirocercosis is caused by the nematode Spirocerca lupi and is characterized by esophageal fibro‐inflammatory nodules that may undergo neoplastic transformation. No sensitive and specific laboratory assays other than histopathology have been reported to differentiate non‐neoplastic from neoplastic disease. Hypothesis/Objectives Dogs with spirocercosis will have evidence of hypercoagulability based on thromboelastography ( TEG )‐derived maximal amplitude ( MA ); increased MA will be correlated with increased acute phase protein ( APP ) concentrations (C‐reactive protein [ CRP ] and fibrinogen); increased MA and APP s will be exacerbated with neoplastic spirocercosis. Animals Thirty‐nine client‐owned dogs with naturally occurring spirocercosis and 15 sex‐matched healthy controls. Methods A prospective comparative study evaluating TEG , activated partial thromboplastin time, prothrombin time, antithrombin ( AT ) activity, platelet count and D‐dimer concentration, and APP s of dogs with non‐neoplastic (n = 24) and neoplastic (n = 15) spirocercosis compared to control dogs. Results Median MA was significantly increased in the non‐neoplastic group ( P < .01) and neoplastic group ( P < .01) compared to the controls. Both APP s were significantly increased in the neoplastic group compared to the non‐neoplastic and control groups. MA was strongly correlated with fibrinogen ( r = 0.85, P < .001) and CRP ( r = 0.73, P < .001). An MA >76 mm provided 96% specificity and 73% sensitivity for differentiation of disease state. Conclusions and Clinical Importance Canine spirocercosis is associated with increased TEG variables, MA and α, and decreased AT activity, which may indicate a hypercoagulable state seemingly more severe with neoplastic transformation. MA was correlated with APP in dogs with spirocercosis and can be used as an adjunctive test to support the suspicion of neoplastic transformation.