Open Access
Effects of a Sustained‐Release Form of Isosorbide Dinitrate on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation
Author(s) -
Yamamoto Y.,
Suzuki S.,
Hamabe L.,
Aytemiz D.,
HuaiChe H.,
Kim S.,
Yoshiyuki R.,
Fukayama T.,
Fukushima R.,
Tanaka R.
Publication year - 2013
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.12184
Subject(s) - isosorbide dinitrate , medicine , left atrial pressure , anesthesia , placebo , hemodynamics , crossover study , heart rate , cardiology , blood pressure , alternative medicine , pathology
Background The effects of isosorbide dinitrate ( ISDN ) have not been sufficiently investigated in conscious dogs with mitral valve regurgitation ( MR ). Objective The objective was to investigate the effects of a sustained‐release form of ISDN (sr‐ ISDN ) on hemodynamics and the autonomic nervous system in dogs with MR . Animals Six healthy Beagles weighing 11.2 ± 2.2 kg (2 years of age; 2 males and 4 females) were used. Methods Experimental, crossover, and interventional study. Dogs with experimentally induced MR were administered placebo, 2, 5, and 10 mg/kg sr‐ ISDN PO on separate days with a 7‐day washout period between randomized dosings. Left atrial pressure ( LAP ) had been recorded continuously from 30 minutes before administration of sr‐ ISDN to 12 hours after administration. Results LAP was significantly decreased after administration in the 5 and 10 mg/kg groups. Significant decrease was observed at 3 and 4 hours after administration in the 5 mg/kg group. In the 10 mg/kg group, significant decrease was observed at 2, 3, 4, 5, 6, 7, 10, and 11 hours after administration. The lowest value was observed at 4 hours after administration in the 5 and 10 mg/kg groups (20.9 ± 4.2 to 15.9 ± 3.9 mmHg, P < .01, and 21.3 ± 4.0 to 13.6 ± 4.2 mmHg, P < .001). Conclusions and Clinical Importance Sustained‐release form of ISDN showed significant decrease of LAP in the 5 mg/kg and 10 mg/kg groups, and duration of effect was dose related.