Open AccessComparative Effect of Carperitide and Furosemide on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation
Author(s) -
Suzuki S.,
Fukushima R.,
Yamamoto Y.,
Ishikawa T.,
Hamabe L.,
Kim S.,
Yoshiyuki R.,
Fukayama T.,
Machida N.,
Tanaka R.
Publication year - 2013
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/jvim.12154
Subject(s) - medicine , furosemide , plasma renin activity , aldosterone , cardiology , beagle , mitral regurgitation , endocrinology , blood pressure , renin–angiotensin system
Background The effects of carperitide on left atrial pressure ( LAP ) in dogs with mitral valve disease (mitral regurgitation, MR ) have not been documented. Objective The objective was to compare the short‐term effects of carperitide versus furosemide on LAP and neurohumoral factors in MR dogs. Animals Six healthy Beagle dogs weighing 9.8–12.6 kg (2 males and 4 females; aged 3 years) were used. Methods Experimental, randomized, cross‐over, and interventional study. Carperitide 0.1 μg/kg/min or furosemide 0.17 mg/kg/h (1 mg/kg/6 h) was administered to dogs with surgically induced MR for 6 hours, and after a 14 day wash‐out period, the other drug was administered. LAP , plasma renin activity, plasma aldosterone, and echocardiographic variables were measured. Results Left atrial pressure was decreased similarly after the administration of carperitide 0.1 μg/kg/min and furosemide 0.17 mg/kg/h (1 mg/kg/6 h) compared with baseline in dogs with MR (Baseline 14.75 ± 3.74 mmHg, carperitide 10.24 ± 4.97 mmHg, P < .01, furosemide 10.77 ± 5.06 mmHg, P < .05). Plasma renin activity and plasma aldosterone were significantly lower after the administration of carperitide than after the administration of furosemide ( P < .05, respectively). Conclusions and Clinical Importance Carperitide significantly decreased LAP in dogs with acute MR caused by experimental chordal rupture. Carperitide can have additional benefits from the viewpoint of minimal activation of neurohumoral factors in the treatment of dogs with MR . Additional studies in dogs with spontaneous disease are warranted.