P064: Hepatitis B surface Antigen (HBsAg) levels in chronic hepatitis B patients ‐ a comparison between patients of different ages and their hepatitisBeAntigen (HBeAg) seroconversion status in a prospective cohort | Zendy

Khairul Azhar Jaafar | Zendy; Qabas Naemah Hadi | Zendy; Mia-D  Mustafa | Zendy; Mohamed Hadzri Hasmoni | Zendy; Hoi Poh Tee | Zendy; Azlida Che Aun | Zendy; Sapari  Satwi | Zendy

Premium

P064: Hepatitis B surface Antigen (HBsAg) levels in chronic hepatitis B patients ‐ a comparison between patients of different ages and their hepatitisBeAntigen (HBeAg) seroconversion status in a prospective cohort

Author(s) -

Khairul Azhar Jaafar,

Qabas Naemah Hadi,

Mia-D Mustafa,

Mohamed Hadzri Hasmoni,

Hoi Poh Tee,

Azlida Che Aun,

Sapari Satwi

Publication year - 2015

Publication title -

journal of viral hepatitis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 100

eISSN - 1365-2893

pISSN - 1352-0504

DOI - 10.1111/jvh.61_12425

Subject(s) - hbsag , seroconversion , medicine , hbeag , chronic hepatitis , prospective cohort study , hepatitis b , cohort , virology , hepatitis b virus , immunology , virus

181b, which are known to regulate germinal centers, Bcell differentiation and activation. Several miRNAs expressed in ALF are upregulated in B-cell lymphomas. In contrast, only a very small number of miRNA were identified that target T-cell genes, in agreement with the limited T-cell signature detected in ALF and with the absence of IFN-c and its inducible chemokines both amongst liver mRNAs and serum proteins. CONCLUSIONS: This is the first genome-wide integrated analysis of mRNA and miRNA expression in HBV ALF. Our results reveal a dominant B-cell-driven disease signature consistent with a major role of B-cell immunity in the pathogenesis of ALF.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research