Premium
P064: Hepatitis B surface Antigen (HBsAg) levels in chronic hepatitis B patients ‐ a comparison between patients of different ages and their hepatitisBeAntigen (HBeAg) seroconversion status in a prospective cohort
Author(s) -
Khairul Azhar Jaafar,
Qabas Naemah Hadi,
Mia-D Mustafa,
Mohamed Hadzri Hasmoni,
Hoi Poh Tee,
Azlida Che Aun,
Sapari Satwi
Publication year - 2015
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.61_12425
Subject(s) - hbsag , seroconversion , medicine , hbeag , chronic hepatitis , prospective cohort study , hepatitis b , cohort , virology , hepatitis b virus , immunology , virus
181b, which are known to regulate germinal centers, Bcell differentiation and activation. Several miRNAs expressed in ALF are upregulated in B-cell lymphomas. In contrast, only a very small number of miRNA were identified that target T-cell genes, in agreement with the limited T-cell signature detected in ALF and with the absence of IFN-c and its inducible chemokines both amongst liver mRNAs and serum proteins. CONCLUSIONS: This is the first genome-wide integrated analysis of mRNA and miRNA expression in HBV ALF. Our results reveal a dominant B-cell-driven disease signature consistent with a major role of B-cell immunity in the pathogenesis of ALF.