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Identification of hepatitis B virus aetiologic antigens, HBx and Pre‐S2, in diffuse large B‐cell lymphoma
Author(s) -
Huang Xinxing,
Young Ken H.,
Guo Wei,
Wang Yinping,
Wang Xueju,
Xi Yanfeng,
Wang Lifen,
Bai Ou
Publication year - 2020
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.13301
Subject(s) - hbx , hepatitis b virus , lymphoma , antigen , hbsag , diffuse large b cell lymphoma , virology , hepatitis b , immunohistochemistry , virus , medicine , cancer research , immunology , biology
Diffuse large B‐cell lymphoma (DLBCL) has been reported to have a significant association with the hepatitis B virus (HBV) infection. However, there has been no experimental evidence to determine whether the components of the hepatitis B virus are expressed in lymphoid cells. In this study, we used immunohistochemical methods to explore whether the antigens of hepatitis B virus are expressed in DLBCL lymphoma cells in HBsAg‐positive DLBCL patients (HBsAg + DLBCL). HBx antigen was detected in 48.9% of HBsAg + DLBCL patients, and the expression rate of the Pre‐S2 antigen was 57.2%. HBx expression was significantly associated with high‐level expression of c‐Myc, while the Pre‐S2 antigen was not. In this study, we demonstrated that HBx antigen and Pre‐S2 antigen could be detected in lymphoma cells, and HBx expression was related to c‐Myc expression. Our findings provide a strong basis for further study of the HBV‐infected DLBCL and molecular mechanism underlying the lymphomagenesis.