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Insights for clinical diagnostic indicators of virus and host in chronic hepatitis B infection
Author(s) -
Ou Qishui,
Guo Jianhui,
Zeng Yongbin,
Chen Huijuan
Publication year - 2020
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.13260
Subject(s) - cccdna , hepatitis b virus , virology , virus , circular dna , chronic hepatitis , immune system , hepatitis b , immunology , medicine , host factors , biology , genome , gene , hbsag , genetics
Abstract Covalently closed circular DNA (cccDNA), which is stably present in the nucleus of hepatocytes, is an important indicator for evaluating antiviral efficacy. Since cccDNA quantification requires an invasive procedure, serum biological markers that can effectively reflect the transcriptional activity of intrahepatic virus and the efficacy of treatment are required. Here, from the aspects of virus and host, we outline the focus of clinical research of HBV in recent years, including HBV RNA, empty virus, hepatitis B core‐related antigen and changes in the immune response. We briefly discuss their significance in predicting disease activity and monitoring treatment response in chronic hepatitis B. On this basis, some issues worthy of attention in laboratory diagnosis are proposed.