Premium
Comparing interferon‐free with interferon‐based regimens in HCV patients: Rogers phenomenon and Simpson’s paradox
Author(s) -
Carrat Fabrice,
Nahon Pierre,
Fontaine Hélène,
Pol Stanislas,
Hejblum Gilles
Publication year - 2020
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.13225
Subject(s) - medicine , confounding , interferon , incidence (geometry) , chronic hepatitis , hepatitis c , oncology , immunology , virus , physics , optics
Comparisons of time‐to‐event clinical outcomes between patients with or without a sustained virological response (SVR) after treatment of chronic hepatitis C infection have been repeatedly reported in emphasizing the potential clinical impact of treatment. Combining recently published data from different therapeutic eras with simple examples, we show that comparisons of incidence rates by SVR status between patients treated with interferon‐based and interferon‐free regimens are flawed through confounding by prognosis. The relevant analysis for evaluating and comparing the clinical impact of these regimens should be a comparison between randomized treatment groups, irrespective of the SVR status.