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Serum protein expression patterns in detecting a new viral protein in HBeAg‐negative chronic hepatitis B
Author(s) -
Chen Huguang,
Luo Shuya,
Lu Weili,
Chen Zhi,
Chen Jiamin,
Zheng Shu,
Yu Jiekai
Publication year - 2019
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.13166
Subject(s) - hbeag , chronic hepatitis , pathogenesis , hepatitis b , hepatitis b virus , virology , medicine , surface protein , immunology , virus , hbsag
We analysed the changes in viral protein expression in HBeAg‐negative chronic hepatitis B (CHB). In total, 160 samples were obtained from individuals infected by hepatitis B virus (HBV) and divided into four groups. Group A included 71 cases of hepatitis B e antigen (HBeAg)‐negative CHB, Group B included 58 cases of inactive seroconverters and Group C included 31 cases of HBeAg‐positive CHB. Group D included 22 normal healthy individuals as a control. All serum samples were examined using surface enhance laser desorption/ionization time of flight‐mass spectrometry (SELDI‐TOF‐MS). The results indicated that a peak with 4140 m/z increased markedly in Group A at 1295.55 ± 745.87, which was significantly different from that in Group B at 896.99 ± 534.86 ( P = 0.013). This peak indicated a close relationship with HBV DNA replication and may contribute to pathogenesis of HBeAg‐negative chronic hepatitis.