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Chronic hepatitis B virus infection and risk of dyslipidaemia: A cohort study
Author(s) -
Joo EunJeong,
Chang Yoosoo,
Yeom JoonSup,
Cho Yong Kyun,
Ryu Seungho
Publication year - 2019
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.13014
Subject(s) - medicine , hbsag , hazard ratio , cohort , hepatitis b virus , proportional hazards model , body mass index , cohort study , confidence interval , hepatitis b , immunology , virus
Summary Hepatitis B virus (HBV) infection has been associated with a decreased prevalence of dyslipidaemia in cross‐sectional studies, but cohort studies are limited. We investigated the longitudinal effects of chronic HBV infection on the development of dyslipidaemia. We performed a cohort study of 62 287 non‐cirrhotic adult men and women free of dyslipidaemia who underwent serologic testing for hepatitis B surface antigen ( HB sAg) and were followed annually or biennially for an average of 4.46 years. A parametric proportional hazard model was used to estimate the adjusted hazard ratio with 95% confidence interval ( CI ) for incident dyslipidaemia according to HB sAg seropositivity status. We identified 12 331 incident cases of hypercholesterolaemia during 278 004.4 person‐years of follow‐up (incident rate 44.4 per 1000 person‐years). In models adjusted for age, sex, body mass index, year of screening exam, smoking status, alcohol intake, regular exercise and education level, the adjusted hazard ratios (95% CI s) for incident hypercholesterolaemia, high LDL cholesterolaemia; hypertriglyceridaemia, high non‐ HDL cholesterolaemia and low HDL cholesterolaemia comparing HB sAg‐positive to HB sAg‐negative participants was 0.71 (0.64‐0.79), 0.83 (0.78‐0.89), 0.61 (0.54‐0.70), 0.69 (0.63‐0.75) and 1.10 (0.98‐1.24), respectively. An inverse association between HB sAg positivity and incident high apolipoprotein B were also identified, with a corresponding a hazard ratio of 0.63 (0.55‐0.72). In a large cohort of apparently healthy Korean adults, HB sAg seropositivity was associated with lower risk of development of dyslipidaemia, suggesting a role of HBV infection in lipid metabolism.