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Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK : A population‐based cohort study using the UK Clinical Practice Research Datalink
Author(s) -
Ferreira G. L. C.,
Marano C.,
De Moerlooze L.,
Guignard A.,
Feng Y.,
El Hahi Y.,
van Staa T.
Publication year - 2018
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12841
Subject(s) - medicine , cohort , incidence (geometry) , diabetes mellitus , cohort study , hepatitis c , retrospective cohort study , confidence interval , poisson regression , population , rate ratio , endocrinology , environmental health , physics , optics
Summary We assessed the incidence and prevalence of hepatitis B (Hep B) in patients with or without diabetes mellitus (DM) using the UK Clinical Practice Research Datalink (CPRD). This was a retrospective, observational study of diabetic and nondiabetic cohorts aged 0‐80 years using CPRD ( NCT 02324218). Incidence rates ( IR ) for each cohort were calculated. Crude and adjusted (Poisson regression) IR ratios ( IRR ) were estimated with 95% confidence intervals ( CI ) to compare the cohorts. Hep B prevalence stratified by age, and hospitalization related to Hep B was also calculated. Of 7 712 043 subjects identified, 4 839 770 were included (DM: 160 760; non‐DM: 4 679 010). Mean ages were 54.4 and 32.0 years, and 57.20% and 50.14% were male in the diabetic and nondiabetic cohorts, respectively. Hep B was identified in 29 diabetic and 845 nondiabetic subjects; IR was 4.03 per 100 000 person‐years and 2.88 per 100 000 person‐years, respectively. The adjusted IRR was 1.00 (95% CI : 0.70‐1.50) between diabetic and nondiabetic cohorts. Hep B prevalence was higher in the diabetic cohort (0.01%‐0.26%) than in the nondiabetic cohort (0.00%‐0.03%) across the different age groups. Hep B‐associated hospitalization IR was higher in the diabetic cohort (4.98‐10.91) than the nondiabetic cohort (0.26‐2.44). The Hep B IR , hospitalization and prevalence were higher in males in both cohorts. In conclusion, the risk of incident Hep B diagnosis in the diabetic cohort was not different from that in the nondiabetic cohort. However, prevalence of Hep B and Hep B‐associated hospitalization rate was higher in the diabetic than in the nondiabetic cohort.