Premium
Quality of life in adolescents with hepatitis C treated with sofosbuvir and ribavirin
Author(s) -
Younossi Z. M.,
Stepanova M.,
Schwarz K. B.,
Wirth S.,
Rosenthal P.,
GonzalezPeralta R.,
Murray K.,
Henry L.,
Hunt S.
Publication year - 2018
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12830
Subject(s) - medicine , sofosbuvir , ribavirin , quality of life (healthcare) , hepatitis c , abdominal pain , cirrhosis , gastroenterology , chronic hepatitis , physical therapy , immunology , virus , nursing
Summary Chronic HCV infection has been associated with impairment of HRQL in both adults and paediatric patients. Our aim was to assess the HRQL of HCV ‐positive children treated with SOF + RBV . The data for this post hoc analysis were collected in a phase 2 open‐label multinational study that evaluated safety and efficacy of SOF (400 mg/day) plus RBV (weight‐based up to 1400 mg/day) for 12 or 24 weeks in adolescents with chronic HCV ( GS ‐ US ‐334‐1112). Patients and their parents/guardians completed the Peds QL ‐4.0‐ SF ‐15 questionnaire at baseline, at the end of treatment and in post‐treatment follow‐up. We included 50 adolescents with HCV genotype 2 and 3 without cirrhosis (14.8 ± 1.9 years; male: 58%; treatment‐naïve: 82%; vertically transmitted HCV : 70%). After treatment, 100% of patients with HCV genotype 2 and 95% with genotype 3 achieved SVR ‐12. During treatment with SOF + RBV , there were no significant decrements in any of patients’ self‐reported or parent‐proxy‐reported PRO scores regardless of treatment duration (all P > .05). After treatment cessation, we recorded a statistically significant improvement in patients’ self‐reported Social Functioning score by post‐treatment week 12: on average, +4.8 points on a 0‐100 scale ( P = .02). By post‐treatment week 24, parent‐proxy‐reported School Functioning score increased by, on average, +13.0 points ( P = .0065). In multivariate analysis, history of abdominal pain and psychiatric disorders were predictive of impaired HRQL in adolescents with HCV ( P < .05). Adolescents with HCV do not seem to experience any HRQL decrement during treatment with SOF + RBV and experience some improvement of their HRQL scores after achieving SVR .