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Performance of rapid diagnostic tests for the detection of antibodies to hepatitis C virus in whole blood collected on dried blood spots
Author(s) -
Poiteau L.,
Soulier A.,
Rosa I.,
RoudotThoraval F.,
Hézode C.,
Pawlotsky J.M.,
Chevaliez S.
Publication year - 2016
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12501
Subject(s) - antibody , dried blood , hepatitis c virus , medicine , virology , whole blood , hepatitis c , immunology , screening test , virus , chemistry , family medicine , chromatography
Summary Rapid diagnostic tests ( RDT s) represent an attractive alternative to enzyme immunoassays. A total of 207 individuals, including 68 HCV ‐seronegative subjects, 10 patients with resolved infection and 129 patients with chronic HCV infection, were studied. The specificity of RDT detection of anti‐ HCV antibodies in whole blood was 100% with the four RDT s tested: OraQuick ® HCV Rapid Antibody Test, First Response HCV Card Test, ASSURE HCV Rapid Test and MultiSure HCV Antibody Assay. Their diagnostic sensitivity varied between 98.6% and 100%. RDT detection of anti‐ HCV antibody in whole blood collected on dried blood spots appears to be a promising new tool for broadscale screening of HCV infection in high‐ to medium‐risk populations.