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The macrophage activation marker CD 163 is associated with IL 28B genotype and hepatic inflammation in chronic hepatitis C virus infected patients
Author(s) -
Dultz G.,
Gerber L.,
Zeuzem S.,
Sarrazin C.,
Waidmann O.
Publication year - 2016
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12488
Subject(s) - medicine , gastroenterology , hepatitis c virus , fibrosis , inflammation , genotype , immunology , hepatic fibrosis , univariate analysis , virus , multivariate analysis , biology , gene , biochemistry
Summary Recent data highlighted the association of the macrophage activation marker CD 163 with histological inflammation and fibrosis in chronic hepatitis C virus ( HCV ) infection. The aim of this study was to investigate the influence of successful antiviral treatment and IL 28B genotypes on macrophage activation reflected by CD 163 levels in HCV infected patients. In a retrospective cohort study, serum sCD 163 levels were correlated with results of liver histopathology, IL 28B genotyping and clinical parameters in 329 patients with HCV infection, 15 healthy controls and in 161 patients who achieved a sustained virologic response after antiviral treatment. sCD 163 levels were significantly higher in patients with chronic HCV infection in comparison to healthy controls (5202 vs 896 ng/mL, P < 0.001). In the multivariate logistic regression analyses, sCD 163 was independently associated with histologically determined inflammation ( P = 0.043) but not with fibrosis ( P = 0.091). sCD 163 dropped significantly after successful antiviral treatment in comparison to baseline values (5202 vs 3093 ng/mL, P < 0.001). In the univariate analyses, sCD 163 was significantly associated with IL 28B genotype (C/C vs C/T+T/T) with higher values in the C/C group (6098 vs 4812 ng/mL, P = 0.003). In the multivariate logistic regression model, sCD 163 levels were significantly associated with IL 28B genotype ( P = 0.003) and sustained virologic response ( SVR ) ( P < 0.001). Our data support the association of activated liver macrophages with hepatic necroinflammation in chronic HCV infection as sCD 163 levels drop rapidly after SVR . The irresponsiveness of IL 28B minor genotypes to interferon might be related to a lower level of macrophage activation in these patients.