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Aspirin inhibits hepatitis C virus entry by downregulating claudin‐1
Author(s) -
Yin P.,
Zhang L.
Publication year - 2016
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12446
Subject(s) - claudin , aspirin , virology , chemistry , virus , biology , tight junction , biochemistry
Summary Aspirin has previously been reported to inhibit hepatitis C virus ( HCV ) replication. The aim of this study was to investigate whether aspirin is involved in blocking HCV entry. We found that aspirin inhibits the entry of HCV pp and infectious HCV . The level of claudin‐1, an HCV receptor, is reduced by aspirin. Our results extend the anti‐ HCV effect of aspirin to the HCV entry step and further reinforce the anti‐ HCV role of aspirin.