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Depression is not associated with peripheral insulin resistance in patients with chronic hepatitis C infection
Author(s) -
Shah S. C.,
Kornak J.,
Khalili M.
Publication year - 2015
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12306
Subject(s) - medicine , depression (economics) , insulin resistance , gastroenterology , cohort , insulin , logistic regression , hepatitis c virus , cohort study , hepatitis c , virus , immunology , economics , macroeconomics
Summary Depression is common in individuals infected with hepatitis C virus ( HCV ), and both depression and HCV infection are independently associated with insulin resistance ( IR ). To evaluate the relationship between depression and IR , among other factors, in an HCV ‐infected cohort. In this cross‐sectional analysis, seventy‐four non‐type 2 diabetic, noncirrhotic, HCV ‐infected patients underwent comprehensive clinical, histologic and metabolic evaluation. IR was assessed directly with an insulin suppression test by measuring steady‐state plasma glucose ( SSPG ) levels during continuous infusions of octreotide, glucose and insulin. Logistic regression modelling was used to evaluate predictors associated with depression. Thirty‐nine (53%) patients were depressed, and 21 (54%) depressed patients were on at least one antidepressant. A higher estimated proportion of depressed patients were C aucasian (51% vs 20%, P = 0.005), unemployed (69% vs 49%, P = 0.07), heavier smokers (18 pack‐years vs 13 pack‐years, P = 0.07), on substance abuse therapy (16% vs 3%, P = 0.06) and had lower HDL levels (1.2 mmol/L vs 1.4 mmol/L, P = 0.01). The mean SSPG levels in depressed and nondepressed patients were 7.3 and 8.3 mmol/L ( P = 0.45), respectively. In multipredictor adjusted analysis, only C aucasian race ( OR 4.19, 95% CI 1.42–12.35, P = 0.009) and lower HDL ( OR 0.95, 95% CI 0.89–0.99, P = 0.046) were associated with depression. In conclusion, although prevalent, depression was not associated with peripheral IR in this HCV ‐infected cohort. Attention to other modifiable factors associated with depression in the HCV ‐infected population is warranted.