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Relationship between polymorphisms near the IL 28B gene and spontaneous HB sAg seroclearance: a systematic review and meta‐analysis
Author(s) -
Lee D. H.,
Lee J.H.,
Kim Y. J.,
Park N. H.,
Cho Y.,
Lee Y. B.,
Yoo J.J.,
Lee M.,
Cho Y. Y.,
Choi W.M.,
Yu S. J.,
Yoon J.H.,
Kim C. Y.,
Lee H.S.
Publication year - 2014
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12193
Subject(s) - meta analysis , genetics , biology , medicine
summary Polymorphisms near the interleukin ( IL ) 28B gene have been proposed to be associated with spontaneous clearance of the hepatitis C virus. The purpose of this study was to assess the relationship between IL 28B polymorphisms and the rate of spontaneous hepatitis B surface antigen ( HB sAg) seroclearance by means of meta‐analysis. MEDLINE /PubMed and EMBASE were utilized to identify relevant studies. Odds ratio ( OR ) and 95% confidence interval ( CI ) were analysed together to assess the strength of the association. Subgroup analyses were mainly performed according to ethnicity. A total of 4028 cases with persistent chronic hepatitis B and 2327 spontaneously recovered controls were included from 11 studies. The single nucleotide polymorphism ( SNP ), rs12979860, had no significant association with HB sAg seroclearance ( OR = 0.98, 95% CI : 0.84–1.14 in the dominant model; OR = 1.00, 95% CI : 0.68–1.46 in the recessive model; and OR = 0.95, 95% CI : 0.82–1.09 in the allelic model). The SNP , rs12980275, had no significant association either ( OR = 1.03, 95% CI : 0.84–1.26 in the dominant model; OR = 1.17, 95% CI : 0.46–2.96 in the recessive model; and OR = 1.04, 95% CI : 0.86–1.26 in the allelic model), nor did the SNP , rs8099917 ( OR = 0.94, 95% CI : 0.77–1.15 in the dominant model; OR = 0.74, 95% CI : 0.34–1.62 in the recessive model; and OR = 0.93, 95% CI : 0.77–1.13 in the allelic model). Similarly, the results of subgroup analyses by ethnicity also showed no association in either the Asian group or non‐Asian group. We concluded that there was no significant association between common IL 28B polymorphisms and the rate of spontaneous HB s A g seroclearance.